AB0569 PSORIATIC ARTHRITIS, ALLIED DISEASES AND MORTALITY - A POSTMORTEM CLINICOPATHOLOGIC STUDY OF 12 PATIENTS

Background: Psoriasis ( P ) may be complicated by psoriatic arthritis (psoriatic arthropathy PsA ), in 15 % of patients [1]. The risk mortality is increased outpatients compared to the general population [2]. Objectives: aim this study was determine or associated diseases an in-patient autopsy population. Methods: At National Institute Rheumatology 11860 died between 1968 and 1998; among them 12 with females 6. mean age 68.17 years, range 86 – 52, onset 53.60, average duration 15.40 years; males 6, 62.83 82 33, 46.67, 3.67 years). All were autopsied. basic disease, complication(s), cause death determined a detailed review extensive histological material, all available clinical pathological reports retrospectively. From each patient total 50-100 tissue blocks 16 organs studied microscopically. confirmed clinically according criteria ACR updated Sukfa (2019) Results: related only one (8.33 %) patients; 33 year old man who pulmonary embolism after synovectomy. In 11 (91.66 allied namely atherosclerosis Ath 9 (75 %), tuberculosis miliary dissemination TB - mTB 1 alcoholic cirrhosis AC %). hypertension HT adult type diabetes mellitus DM 4, present without (Table 1). AA amyloidosis AAa 2 (16.66 case due long standing severe inflammation , other . Table 1. P-PsA Basic disease (leading death) Complication(s) Cause Ath, Adhesive pericarditis pleuritis Circulatory failure Ath-HT-DM Hyperplasic prostate Postoperative complication Pulmonary 3 Brain necrosis, 4 Purulent bronchitis-Bronchopneumonia 5 TB-mTB AAa, Arosion bronchial artery Massive bleeding 6 Coronary thrombosis Myocardial infarction 7 Synovectomy 8 fibrosis 10 Alcoholic Ascites, bronchitis cirrhosis, HT-DM Ascites Hepatorenal syndrome Conclusion: our (with most important leading circulatory patients. Diseases system also common Wong’s outpatient as well not mild but life-threatening however association it increase mortality, found Arumugam McHugh (2012): ‘the more disease’ [3]. References: [1] https://www.rheumatology.org/I-Am-A/Patient-Caregiver/Diseases-Conditions/Psoriatic-Arthritis#sthash.kN0iC8N7.dpu [2]Wong K, et al: Arth Rheum 1997; 40(10):1868-1872 PMID: 9336423 [3]Arumugam R, NJ: J Rheumatol Suppl 2012; 89:32-5. doi: 10.3899/jrheum.120239 Disclosure Interests: None declared.